Tetroxy 20 LA

Drug Category:  Antibiotic

Pharmaceutical Form: Sterile Injectable Solution.

Composition: Oxytetracycline base 200 mg/ml.

Mechanism of Actions:

Oxytetracycline is a broad – spectrum antibiotic, highly effective against a large number of pathogenic organisms. Its action is bacteriostatic and based on the inhibition of glutamic acid metabolism in the cells, thus blocking the synthesis bacterial proteins. Oxytetracycline inhibits most gram-positive bacterial, some gram-negative bacteria, rickettsia, mycoplasmas, spirochetes, protozoa and actinomycetes. 

Oxytetracycline binds reversibly to bacterial 30S ribosomes and inhibits protein synthesis, perhaps by several mechanisms. Mainly, the binding of aminoacyl-tRNA to the acceptor site on the mRNA-ribosome complex seems to be impaired

Indications:

Tetroxy 20 LA is active against wide range of Gram- positive and Gram-Negative pathogenic bacteria, certain rickettsia. Tetroxy 20 LA is indicated in the treatment and control of a wide range of common systemic respiratory, gastro- intestinal, urinary, local infections, Metritis, pyodermitis, anaplasmosis.

‍‍‍Cattle: Treatment and control of pasteurellosis, pneumonia, keratoconjunctivitis, Foot rot.

Sheep: Treatment and control of pasteurellosis, pneumonia, keratoconjunctivitis, Foot rot, Enzootic Abortion, Acute Mastitis

Dosages and Administration Routs:

Cattle &Sheep: 20 mg per kg bodyweight (1 ml per 10 kg bodyweight). Following intramuscular administration effective blood levels persist for 3 - 5days. Maximum blood levels are achieved between 4 - 6 hours following administration making Tetroxy LA 20 suitable for the treatment of acute infections.

By deep intramuscular or SC injection.

Adverse and Common Side Effects:

High doses of tetracycline have incriminated in causing renal failure in feed lot cattle

Occasional hypersensitivity reactions may occur.

General toxicity is low although collapse has been reported with tetracycline in week or debilitated animals.

Contra Indication:

Rapid IV injection of a oxytetracycline can produce hypotension and sudden collapse. Oxytetracycline is also potentially nephrotoxic and is contraindicated in renal insufficiency.

Swelling, necrosis, and yellow discoloration at the injection site almost inevitably occur.

Withdrawal time: Meat: 21 days after last treatment.

 Milk: 3 days after last treatment.

Pharmaceutical Precautions:

Store below 30°C, protected from light. Do not freeze.

Packaging: 50 ml and 100 ml glass vial.