Antibiotics
Tetronix
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Oxytetracycline is a broad – spectrum antibiotic, highly effective against a large number of pathogenic organisms. Bacterial proteins. Oxytetracycline binds reversibly to bacterial 30S ribosomes and inhibit protein synthesis, perhaps by several mechanisms.
Drug Category: Antibiotic + NSAIDS
Pharmaceutical Form: Sterile Injectable Solution.
Composition: Oxytetracycline HCl 100 mg/ml
Flunixin (meglumine) 20 mg/ml.
Mechanism of Actions:
Oxytetracycline is a broad – spectrum antibiotic, highly effective against a large number of pathogenic organisms. Bacterial proteins.
Oxytetracycline binds reversibly to bacterial 30S ribosomes and inhibit protein synthesis, perhaps by several mechanisms. Mainly, the binding of aminoacyl-tRNA to the acceptor site on the mRNA- ribosome complex seems to be impaired. Flunixin through inhibition of cyclooxygenase, blocks synthesis of eicosanoids, including prostaglandins, thromboxane, and prostacyclin (PGI2), which are chemical mediators of inflammation. Of NSAID, Flunixin is considered to be the most potent cyclooxygenase inhibitor.
Indications:
This drug is active against wide range of Gram- positive and Gram-negative pathogenic bacteria, certain rickettsia. Oxytetracycline is indicated in the treatment and control of a wide range of common systemic respiratory, gastro- intestinal, urinary, local infections, Metritis, pyodermitis, anaplasmosis. Flunixin provides effective anti-inflammatory and analgesic action in a wide range of musculoskeletal disorder in horses, dogs and cattle.
Dosages and Administration Routs:
10 mg per kg bodyweight (1 ml per 10 kg bodyweight) for 3-5 days.
By deep intramuscular or IV injection.
Adverse and Common Side Effects:
High doses of tetracycline have incriminated in causing renal failure in feed lot cattle
Occasional hypersensitivity reactions may occur.
General toxicity is low although collapse has been reported with tetracycline in week or debilitated animals.
Contra Indications:
Oxytetracycline is also potentially nephrotoxic and is contraindicated in renal insufficiency.
Swelling, necrosis, and yellow discoloration at the injection site almost inevitably occur.
Withdrawal time: Meat: 35 days after last treatment.
Milk: Do not use in dairy cattle.
Pharmaceutical Precautions:
Store below 30°C, protected from light. Do not freeze.
Packaging: 50 ml and 100 ml glass vial.
