Propen 5

Dosage Form: Sterile Powder For injectable Suspension

 Category: Antibiotic

 Composition: Each vial contains 5000.000 IU penicillin G Procaine

Mechanism of Actions:
Penicillin's exert their bactericidal effects by prevent cell wall Synthesis and
Disrupting bacteria cell wall integrity Penicillin's impair the development of bacterial cell walls by interfering with transpeptidase enzymes responsible for the formation of the cross- link between peptidoglycan strands.

 PHARMACOKINETICS:
Penicillin are rapidly absorbed when injected in aqueous suspension by the IM or SC rout. Maximum blood concentrations result in 15-30 minutes. Penicillin G in blood is in plasma and less than 10% is found in erythrocytes. Penicillin G is partially metabolized in the body by unknown mechanisms, however; approximately 90 % of the drug is excreted unchanged. The distribution of penicillin is rapid but not uniform in various fluids and tissues. Penicillin G is excreted primarily in urine, 60 – 100 % of the dose is ordinarily recovered from urine following injection of an aqueous solution.

  INDICATIONS: Penicillin is indicated for use in cattle and sheep in the treatment of systemic infections caused by or associated with organisms sensitive to penicillin including corynebacterium.pyogenes,Listeria, Pasteurella. haemolytica, pasteurella. multocida, staphylococcus and Streptococcus.
Penicillin is recommended, therefore, in the treatment of diseases caused by susceptible organisms including: Navel / joint-ill, respiratory tract infection including pneumonia and atrophic rhinitis, listeriosis, septicemia, urogenital tract infections and the control of secondary bacterial invaders in diseases of primary viral origin.

 Dosages and administration:
10,000 – 30,000 IU / Kg bodgweight, once daily by intramuscular injection.

 ADVERSE AND COMMON SIDE EFFECTS:
Hypersensitivity reactions to penicillin's are the most common untoward reaction and can occur with any penicillin group.
Allergic reactions to these substances are occasionally serious.
Procaine Penicillin should not is administered intravenously.

 Contra- Indication, warning, etc:
In animals show anaphylactic reaction to penicillin should not be used.
Animals treated by the penicillin should be under care for at least half hour.
In case anaphylactic reaction , immediately epinephrine or antihistamine must be administered. 

 DRUG INTERACTIONS:
Various penicillin's can inactivates invitro. Probenecid markedly decreases the tubular secretion of the penicillin.

 Withdrawal times:
Milk: 3 days from last treatment.
Meat: 10 days from last treatment.

 Pharmaceutical precautions:
Store at room temperature, not exceeding 25ºC. Protect from light. Keep out of reach of children.

 Package quantities: 20ml vial.