Tylosol 20

Drug Category:  Antibiotic

Pharmaceutical Form: Sterile Injectable Solution.

Composition: Each ml of Solution contains 200 mg of Tylosin base activity

MECHANISM OF ACTIONS: Tylosin is a macrolide antibiotic with activity against gram – negative and gram-positive bacteria, spirochetes, chlamydia, and mycoplasma organisms. Macrolides interfere with protein synthesis by reversibly binding to the 50S subunit of the ribosome. They appear to bind at the donor site, thus preventing the translocation necessary to keep the peptide chain growing.

 PHARMACOKINETICS: Tylosin is rapidly absorbed after injection. The plasma half – lives of macrolides usually are 1-3 hr, and apparent volumes of distribution of 1000-2000 ml/kg reflect the extensive tissue distribution. Effective inhibitory concentrations are maintained for 12-24 hr after IM injection. Dosage frequencies are commonly 1-2 times /day parenterally.

 INDICATIONS
:Tylosin is indicated in all conditions associated with bacteria sensitive to Tylosin which includes organisms in the following genera
Streptococcus , Bacillus , Staphylococcus , Corynebacterium Clostridium , vibrio , Spirochetes , mycoplasma , Fusiformis , Pasteurella , Chlamydia . General indications include upper respiratory tract infections ,Bronchopneumonia, bacterial enteritis, metritis, pyodermitis, Urinary tract infections and arthritis. Acute Agalactia from mycoplasma.agalactiae

 Dosages and administration
Tylosin should be given by intramuscular injection
10 mg per kg bodyweight for 3-5 days
Sheep: For treatment of abortion from chlamidiae: 400 mg for 2 days

 ADVERSE AND COMMON SIDE EFFECT
Toxicity and side effects are uncommon for most Macrolides although pain and Swelling may occur at injection sites. Hypersensitivity reactions have occasionally been seen. Anorexia, diarrhea, and local pain with intramuscular injection are reported

Contra- indication
Injection of Tylosin in horses has been fatal. Do not use in human

Drug Interactions
Tylosin may increase serum digitalis levels

 Withdrawal times
Milk: 3 days from last injection
Meat: 21 days from last injection

Pharmaceutical Precautions
Store at room temperature, not exceeding 30º C, protected from light .Do not freeze

 Package quantities: Multi dose glass vials Containing 100 ml