Beplex

Category: vitamin

Pharmaceutical Form: Sterile Injectable Solution.

Composition: Vitamin B1(Thiamin HCl) 10 mg/ml,
Vitamin B2(riboflavin5 phosphate ) 4 mg/ml ,
Vitamin B6 ( pyridoxine HCl ) 4 mg/ml , Nicotinamide 50 mg/ml ,
D-Panthenol 2 mg/ml & Vitamin B12 ( Cyanocobalamin ) 10 µg/ml .

MECHANISM OF ACTIONS:
The B complex vitamins are widely distributed in both plant and animal food sources Thiamine after absorption is Converted, probably in the liver, into aneurine pyrophosphate (co – carboxylase). As such, it acts as a coenzyme for several decarboxylating enzyme systems. The most important of which is probably decarboxylase. These enzymes is necessary for the decarboxylation of pyruvic acid, well known as an intermediate stage in carbohydrate build – up or break down. After absorption Riboflavin (B2) is phosphorylated, forming two coenzymes:

1- Riboflavin phosphate, which Consists of one molecule of riboflavin and one of phosphoric acid:
2- Riboflavin adenine dinucleotide, which is one molecule of riboflavin, one of adenine and two of phosphoric acid.

The simple phosphate coenzymes (1) associated with various flovoprotein enzymes including cytochrome – C reductase and L – amino – acid oxidase. The most complex compound (2) is coenzyme to D- amino – oxidase, xanthine oxidase, aldehyde oxidase and others. Riboflavin thus has a direct effect on the metabolism of carbohydrates, aminoacids and aldehydes .pyridoxine exists naturally and also as its aldehyde and as an amine form. After absorption pyridoxine is utilized, probably as the aldehyde, in the formation of coenzymes.
The ester pyridoxal – 5 – phosphoric acid is formed, which is the coenzyme for decarboxylase and also for transaminase. These enzymes are involved in the metabolism of proteins and amino acids . After absorption Nicotinic acid undergoes methylation in the liver. After the vitamin has been assimilated, the acid is converted into nicotinamide. Nicotinamide enters into combination in the tissues with the purine adenine, and phosphoric acid, to form two coenzyme systems, the coenzymes containing nicotinamide therefore act as hydrogen carriers in the oxidation reduction processes of cell metabolism, for which they appear to be essential. Adequate vitamin B 12  is also necessary for maintaining normal levels of sulphydryl groups in the reduced state. The metabolic actions are reflected in the importance of Cyanocobalamin in:

1-maintaining normal haemopoiesis in the bone marrow and elsewhere
2-The formation and maintenance of the myelin sheaths of nerve fibers. In general, Cyanocobalamin plays an important port in the maintenance of all tissues in which protein and nucleoprotein synthesis and fat conversion occur.

PHARMACOKINETICS:
The B.complex Vitamins are water- soluble vitamin. After injection rapidly absorbed and through blood circulation distributed to other organ. Excretion is rapid from the body.

INDICATIONS:
Vitamin B-Complex is indicated in the prevention and treatment of vitamin deficiencies in animals, particularly during periods of illness, convalescence, Stress, general unthriftiness, Anorexia, Anemia.

Dosages and administration:
By intramuscular or subcutaneous injection.
Horses, Cattle & Calves: 3-5 ml /25kg bodyweight.
Sheep& goats: 1-2 ml/15 kg bodyweight.
Dogs & Cats: 1 ml/5 kg bodyweight.

Contra – indication, Warning, etc: For veterinary use only. Do not us in human.

Withdrawal time: Nil

Pharmaceutical Precautions: Store below 30°C, protected from light .Do not freeze.

Package quantities: Multidose vials of 20 ml,50ml and 100ml.