Pirocarb

Category:  Anti- haemprotozoans Drugs

 Pharmaceutical Form: Sterile Injectable Solution

 Composition:Imidocarb Dipropionate 120 mg/ml (12%w/v) ~Imidocarb 85 mg /ml

 

Mechanism of Actions
It appears that Imidocarb acts directly on the parasite, causing an alteration in number and size of nuclei and in morphology. The antiparasitic activity of the aromatic diamidines may be related to interference with aerobic glycolysis as well as interference with synthesis of deoxyribonucleic acid (DNA) in the parasite

 PHARMACOKINETICS
Imidocarb is absorbed rapidly following subcutaneous administration. Imidocarb was found to be bound to plasma protein and detectable amounts were found in all major tissues up to weeks after intramuscular administration. The major rout of excretion appears to be in the urine, although 10% is excreted in the faeces. Imidocarb is excreted unchanged

 INDICATIONS
Imidocarb is recommended for the treatment and prophylaxis of Babesiosis and anaplasmosis

 DOSAGE
:Babesiosis
For treatment: Cattle, Sheep: 1 ml per 100 kg bodyweight. May be, would be need 24 hrs later
For prevention and Sterilization: Cattle: 2.5 ml per 100 kg bodyweight
Anaplasmosis
Cattle: 2.5 ml per100 kg body weight

ADMINISTRATION ROUTS
Imidocarb must be administrated Subcutaneously, Preferably in the neck

 ADVERSE AND COMMON SIDE EFFECTS
Imidocarb must not be administered intravenously. Animals may show cholinergic signs after dosing. It may be possible to alleviate these side effects by treatment with atropine sulfate. Deaths from anaphylactic reaction have been recorded following product use

 Further information: when used for prevention Imidocarb should be administered when clinical signs of the disease are observed in one or two cattle of a group or at the time of moving susceptible cattle into an area of known Babesia challenge. The entire group of animals should be dosed to provide protection against Babesiosis, and all must be kept to the with hold times shown above

 Withdrawal time
Meat: 28 days after last treatment
Milk: milk must not be taken for human consumption from cattle until after at least 21 days from any treatment

 Pharmaceutical precautions
Store below 25°C. Protect prom light. Do not freeze

 Package quantities: vial of 20 ml