Iverject

Category: Antiparasite.

 Pharmaceutical Form: Sterile Injectable Solution.

 Composition:Each ml Contains Ivermectin 10 mg.   

Mechanism of Actions:
Ivermectin is a semi synthetic derivative of avermectin that has a broad spectrum of activity against a wide variety of arthropods and nematodes of wild and domestic animals. Ivermectin increased the release of g amino butyric acid (GABA) from synaptosomes of the nervous system. This, inturn, opened GABA – gated chloride channels. Ivermectin has been shown to cause paralysis by affecting g amino butyric acid (GABA) mediated signals between nerves and muscles. Flukes and tapeworms are thought not to use GABA as a neurotransmitter.

PHARMACOKINETICS:
Ivermectin is readily absorbed, especially when given parenterally. Peak plasma concentration are reached 4.4 hr after dosing directly into the abomasums (with 100% bioavailability), but 23.5 hr after dosing intraruminally, which suggests the drug is rapidly metabolized in the rumen. High concentration of drugs is sustained in the tissues for long periods, particularly after parenteral administration. Drug residues occur mainly in the liver and fat with very little in the muscle. The bulk of drug is excreted in the feces (98%) with only 2% in the urine.

INDICATIONS:
Ivermectin is a broad spectrum antiparasitic agent. It is used in large animals for the eradication of adult and most larval stages of most gastrointestinal round worms and lung worm, and ectoparasities, such as lice, mites, and certain insect larva.

 CATTLE AND SHEEP: Ivermectin administered to Sheep and cattle results in efficacies of 97-100 % against adult and 4the-stage larval forms of respective species:

1- Gastro – intestinal worms: Heamonchus, ostertagia, Cooperia, Trichostrongylus, Nematodirus, Trichuris, Oesophagostomum, Dictyocaulus,

2- Lungworm: Dictyocaulus. Viviparous

3- Mites: Sarcoptes . Bovis, psoroptes ovis.

4-Sucking lice: Lingonathus Vituli, Hematopinus. Eurysternus,

 L. pedalis.

5- Ticks: ornithodrus. Savini, Boophilus

6- Hypoderma. Bovis , Hypoderma. Lineatum, Oestrus Ovis

DOGS: For the prevention of heartworm: Dirofilaria immitis.

DOSAGE:
Cattle, Sheep & Camel: 1 ml per 50 kg bodyweight.equivalent to 0.2 mg per kg body weight.
Dogs: 0.006 mg per kg bodyweight.

Administration Routs:
In cattle and sheep inject subcutaneously in front of, or behind, the shoulder.

ADVERSE AND COMMON SIDE EFFECTS:
Ivermectin has a wide margin of safety. This product is not for intravenous or intramuscular use. Ivermectin may be toxic in certain breeds of dogs (i.e. collies). Transitory discomfort has been observed in some cattle following subcutaneous administration.

 Environmental Safety:
Studies indicate that when Ivermectin comes in contact with the soil, it readily and tightly binds to the soil and becomes inactive. Drug containers and any residual Contents should be disposed of safely , e.g., by burning in waste ground a way from water courses , as free Ivermectin  may adversely affect fish and certain water- borne organisms.

Withdrawal time:
Meat: 21 days after last treatment.
Do not use in Cattle producing milk for human consumption.

Pharmaceutical precautions:
Store at room temperature, not exceeding 30°C, protected from light. Do not freeze.

Package quantities: 20 ml and 100 ml amber glass vial.