Idocure

Drug Category: Antimicrobial

Drug Form: Sterile Injectable Solution.

Composition: Each ml contains 32 mg of potassium iodide.

Mechanism of action:

It is a biologically active compound that has antibacterial and antiviral properties with a wide range of activities that affect gram-positive, gram-negative bacteria as well as viruses containing DNA and RNA. The active ingredient in this product is a combination of potassium iodide with water-soluble polymers, polysaccharides and natural proteins. Pharmacokinetics:

After injection, the drug rapidly reaches the therapeutic level in tissues, organs and body fluids (blood plasma, milk and urine). In the muscles of the heart, liver, thyroid, spleen, lymph nodes, kidneys, lungs, and skeletal muscle, the concentration of the drug remains for 18 to 24 hours, after which the drug begins to be excreted rapidly. In plasma, the therapeutic concentration is maintained for up to 16 hours.

The maximum concentration of the drug after intramuscular injection is 2 hours after injection and after subcutaneous injection 2 to 3 hours after injection. Depending on the animal, the half-life is 48-36 hours. Complete elimination of the drug occurs 72 hours after ingestion. Excretion occurs mainly through urine, milk, and to a lesser extent feces and bile. Because it is an iodofluorine drug, it is eventually released and metabolized as iodine complexes at the site of the lesion. The final metabolite is free iodide ions.

Indications:

It is active against gram-negative bacteria: Salomonella, Pseudomonas, Proteus, Bacillus, Escherichia coli, Brucella, Pasteurella, Pyogenes, Yersinia, Klebsiella, Pneumonia and Corynebacterium.

It is active against gram-positive bacteria: Staphylococcus, Streptococcus, Diplococcus, Enterococcus, Mycobacterium and Listeria.

It is active against DNA-carrying viruses: herpes virus, Capri Pax virus, adenovirus, intoxicating adenovirus and circus virus.

It is active against RNA viruses: rhinovirus, post-virus, paramyxovirus, orthoxyvirus, aphthovirus, cardiovirus, coronavirus, rotavirus, polio virus, hepatitis C virus.

This drug is used in the treatment and prevention of infectious diseases: malaria, aerobic dysentery, tuberculosis, listeriosis, streptoderm, otitis media, gastroenteritis, influenza, parainfluenza, viral hepatitis, myocarditis, myxomatosis, viral diarrhea, bronchopneumonia, bronchopneumonia, bronchopneumonia Infectious, smallpox, foot and mouth disease, plague and Pseudorabies are effective.

Dosages and Administration Route:

It is administered intramuscularly, intravenously and subcutaneously.

 0.1 to 0.3 mg per kg body weight for 3 to 7 days depending on the severity of the disease.

The drug should be diluted 1 to 10 in normal saline or water for injection before injection. In intravenous injection, the injection rate is 0.25-0.8 ml / min for 10 to 20 minutes.

In young birds, orally dilute 30 ml of the drug per 100 birds in a ratio of 1 to 30 in drinking water.

Side effects:

Injecting large doses of the drug may lead to nausea, vomiting, impaired coordination of movements, seizures and parasites, spasm, shortness of breath, decreased heart rate, hypotension, lymphocytosis and thrombocytosis.

Contraindications: 

There is no limit to use during pregnancy and lactation.

Drug interactions:

Concomitant use of this drug with penicillins and streptomycins is not allowed.

Due to the high antimicrobial activity of the drug, the use of live vaccines up to 2 days after drug administration is not recommended.

Pharmaceutical precautions:

Store the drug at a temperature below 25 ° C and away from light. Prevent the medicine from freezing.

Packaging: 20, 50 and 100 ml vials.