Fertirelin

Category: Hormone

Pharmaceutical Form: Sterile Injectable Solution.

Composition: Gonadorelin (as acetate) 100 µg/ml

PHARMACOLOGY:
Gonadorelin is a decapeptide hypothalamic releasing factor responsible for stimulating the release of FSH and LH from the anterior pituitary gland. Administration of Gonadorelin releases LH and FSH from the anterior pituitary gland with peak levels occuring after 1-2 hours and the levels then decline rapidly within 4-6 hour. The gonadotrophic hormones control the estrous cycle of the female and modulate testicular function in the male. In the female, FSH is responsible mainly for growth of the follicle by binding to granulosa cells and stimulating oestradiol production. LH is responsible for final maturation and ovulation by binding to the thecal cells of the developing follicle and stimulating the synthesis of androgens. These androgens, mainly testosterone and androstenedione, diffuse across to the granulosa cells, and are converted to oestradiol- 17β by the aromatase system. This is activated by FSH.

 INDICATIONS:
Gonadorelin is indicated for the treatment of cystic ovaries in cattle. It may be used in breeding cattle:
-  Prior to treatment with a prostaglandin for the induction of oestrus in dairy cows.
-  In association with to optimize the time of ovulation improving the conception rate.
-  In the early post- Partum period to initiate normal ovarian activity.

Dosage and administration:
Cattle:
For treatment of ovarian cyst: 5 ml (500 µg Gonadorelin) by deep IM injection.
Other Indications: 2.5 ml (250 µg Gonadorelin) by deep IM injection.

Contra- indication, warning, etc:
Not to be given to animals known to be hypersensitive to the active ingredient.

Withdrawal time: Nil.

Pharmaceutical Precautions:
Store below 25ºC, protected from light. Do not freeze.

Package quantities: 20 ml vials.